14, July 2020

ESA Open Invitation to Tender AO10318
Open Date: 08/07/2020
Closing Date: 16/09/2020 13:00:00

Status: ISSUED
Reference Nr.: 20.1EP.02
Prog. Ref.: Technology Developme
Budget Ref.: E/0901-01 – Technology Developme
Tender Type: C
Price Range: 200-500 KEURO
Products: Satellites & Probes / System Engineering Software / System Modelling & Simulation / Modelling tools (Model development, Non real-time execution, Code generation, …)
Technology Domains: Spacecraft Environments and Effects / Environment Effects / Effects Analysis Tools / Spacecraft Environments and Effects / Space Weather / Modelling Development and IT Infrastructure
Establishment: ESTEC
Directorate: Directorate of Tech, Eng. & Quality
Department: Electrical Department
Division: Power Systems, EMC & Space Environ.Div
Contract Officer: Seynaeve, Christophe Rene R.
Industrial Policy Measure: C3 – Activities restricted to SMEs & R&D organisations, prefe…
Last Update Date: 08/07/2020
Update Reason: Tender issue

Biological effects of radiation in space missions expose astronauts to health risks that need to be quantified and possibly minimised in order to enable a human exploration programme. The space radiation environment differs from the terrestrial one, including highly variable fluxes of energetic protons from Solar activity, and highly ionising, penetrating ions from Galactic Cosmic Rays with lower intensity but higher biological damage effectiveness.The development a European Space Radiation Risk Model was indicated as priority by the ESA Topical Team in Investigation of Biological Effects of Radiation (IBER). In support to this development, improvements are needed in the understanding of detailed interaction of radiation at DNA and cellular level, complementing macroscopic damage models. Damage and risk models shall serve as input to human space flight mission design and operation, within the current workflows or as part of new tools such as those envisaged as part of e.g. The erfnet or SEPEM studies. Modelling of radiation interactionsat nanometre / micrometre scale requires Monte Carlo transport tools capable of describing physical interactions with the cellular materials down to extremely low energies. The Geant4-DNA activity, initiated by ESA and profiting from the contribution of an international collaboration, has laid the foundations for detailed track-structure simulations, extending the models to DNA damage throughphysico-chemical and chemical processes. This activity encompasses the following tasks:- extensions to the physics and chemistry models, and new models for description of DNA repair mechanisms and other biological effects, aiming at enabling comparisons with experimental observables.- assembly of a simulation platform able to work at different spatial and temporal scales: from early damage tomid and long term time scales (minutes, hours, days); at cellular, full body, and S/C and planetary habitat scale.- Validation of damage quantification and repair processes through irradiation campaigns (eg. DSB using immunofluorescence staining) at micro-beams,and through comparison to space-based measurements (e.g. From biochips). Design of further relevant space-based measurements.Procurement Policy: C(3) = Activity restricted to SMEs RD Entities. For additional information please go to EMITS news “Industrial Policy measures for non-primes, SMEs and RD entities in ESA programmes”.

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